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HRID74803

反应详情

EQUATION

反应方程式

HRID 74803 的结构方程式

REACTANTS

反应物

2
结构：CCNCC
HCID8021

Diethylamine

C4H11N

结构：CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)NCCC1C=CC=CC=C1)OC)N(C)C(=O)[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(C)C
HCID89582252

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)NCCC1C=CC=CC=C1)OC)N(C)C(=O)[C@@H](N)C(C)C
HCID86685760

未命名化合物

收率 87%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

According to the general procedure A, from #175 (560 mg, 0.690 mmol, 1 eq.) in dichloromethane (9 mL), and N,N-diethylamine (6.0 mL), was synthesized the crude desired compound, which was purified by by silica gel chromatography (Gradient: 0 to 50% methanol in dichloromethane) to afford #176 (351 mg, 87%) as a yellow oil. LC-MS (Protocol Q1): m/z 589.5 [M+H+], retention time=0.72 minutes.

WORKUP

后处理

  1. customwas synthesized the crude desired compound, which
  2. customwas purified by by silica gel chromatography (Gradient: 0 to 50% methanol in dichloromethane)