反应详情

To (2-ethyl-1-{1-[(4-methylphenyl)sulfonyl]-1H-pyrazol-5-yl}butyl)amine (0.200 g, 0.630 mmol) in CH2Cl2 (10 mL) was added triethylamine (0.18 mL, 1.3 mmol) and 5-chlorothiophene-2-sulfonyl chloride (0.14, 0.76 mmol) After 1 day the reaction mixture was diluted with chloroform (30 mL), washed with H2O (2×30 mL), dried (Na2SO4) and concentrated. Column chromatography (EtOAc/hexane, 3:7) provided 5-chloro-N-(2-ethyl-1-{1-[(4-methylphenyl)sulfonyl]-1H-pyrazol-5-yl}butyl)thiophene-2-sulfonamide (0.104 g, 33%) as a white solid (mp=146-148° C.).

1. washwashed with H2O (2×30 mL)
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated