反应详情

To a stirred solution of 2-ethyl-1-[1-(4-fluorobenzyl)-1H-1,2,4-triazol-5-yl]butan-1-ol (0.459 g, 1.42 mmol) in DMF (10 mL) was added sodium azide (0.277 g, 4.26 mmol) and the mixture was heated to reflux for 3 h. After cooling, the reaction mixture was diluted with H2O and extracted with EtOAc twice. The organic extracts were dried (MgSO4), filtered, concentrated in vacuo and purified by column chromatography (SiO2, EtOAc/hexane, 1:9) to yield a clear oil in 67% yield.

1. temperaturethe mixture was heated
2. temperatureto reflux for 3 h
3. temperatureAfter cooling
4. extractionextracted with EtOAc twice
5. dry with materialThe organic extracts were dried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. custompurified by column chromatography (SiO2, EtOAc/hexane, 1:9)
9. customto yield a clear oil in 67% yield