Acetaldehyde → HCID 68594649, compound

HRID 748066Notes

Reaction equation

HRID 748066 reaction equation
[CH3:1][C:2]1[CH:13]=[CH:12][C:5]([CH2:6][N:7]2[CH:11]=[N:10][CH:9]=[N:8]2)=[CH:4][CH:3]=1.[CH:14](=[O:16])[CH3:15]>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:11]([CH:14]([OH:16])[CH3:15])=[N:10][CH:9]=[N:8]2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 177AcetaldehydeHCID 20552294HCID 20552294, compound

Product 1

HCID 68594649HCID 68594649, compoundYield 86%

Procedure

1-[1-(4-Methylbenzyl)-1H-1,2,4-triazol-5-yl]ethanol was synthesized in a manner similar to that of the procedure in Example 21B but using 1-(4-methylbenzyl)-1H-1,2,4-triazole and acetaldehyde as the starting materials. The product was isolated as a white solid in 86% yield. 1H NMR (400 MHz, DMSO-d6) δ 1.26 (d, 3H, J=6.9 Hz), 2.22 (s, 3H), 3.27 (s, 1H), 4.88-4.94 (m, 1H), 5.66 (d, 2H, J=5.91 Hz), 7.09 (s, 4H), 7.79 (s, 1H).

Workup

  1. customThe product was isolated as a white solid in 86% yield

Sources & evidence

ORD record
ord-207818bfa0ae4c9ea7c1e9e92e177053
Source dataset
uspto-grants-2008_07
Patent number
US07399778B2

Reaction notes

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