Pyridine-2-carbonitrile → HCID 59750340, compound

HRID 748092Notes

Reaction equation

HRID 748092 reaction equation
[CH3:1][O:2][C:3]1[C:4]([SH:12])=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=O.[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)#[N:14]>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[C:4]2[S:12][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[N:14][C:6](=[O:8])[C:5]=2[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 7522Pyridine-2-carbonitrileHCID 166556102-Mercapto-3-methoxybenzoic acid

Product 1

HCID 59750340HCID 59750340, compoundYield 28%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
135 °C

Procedure

A mixture of 3-methoxy-2-mercaptobenzoic acid (1.84 g, 10.0 mmol), 2-cyanopyridine (1.05 g, 10.2 mmol) and pyridine (30.0 ml) was refluxed at 135° C. for 18 hrs as described in Example 9. The mixture was concentrated. The obtained crystals were recrystallized from ethanol to give the titled compound (0.75 g, 28%).

Workup

  1. concentrationThe mixture was concentrated
  2. customThe obtained crystals were recrystallized from ethanol

Sources & evidence

ORD record
ord-ea5ac8311f524492a103455dfc83fa85
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

Loading…