Pyridine-2-carbonitrile → HCID 59750441, compound

HRID 748098Notes

Reaction equation

HRID 748098 reaction equation
[SH:1][C:2]1[C:10]([CH3:11])=[CH:9][C:8]([CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)#[N:14]>N1C=CC=CC=1>[CH3:12][C:8]1[CH:9]=[C:10]([CH3:11])[C:2]2[S:1][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=3)=[N:14][C:4](=[O:6])[C:3]=2[CH:7]=1

Participants

4

Reactant 2

HCID 7522Pyridine-2-carbonitrileHCID 22939285HCID 22939285, compound

Product 1

HCID 59750441HCID 59750441, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 2-mercapto-3,5-dimethylbenzoic acid (1.6 g, 8.8 mmol), 2-cyanopyridine (1.0 g, 9.7 mmol) and pyridine (15 ml) was refluxed for 12 hrs as described in Example 9. After cooling, the precipitated crystals were collected by filtration and recrystallized from hexane-chlorobenzene to give the titled compound (1.2 g, 52%).

Workup

  1. temperaturewas refluxed for 12 hrs
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were collected by filtration
  4. customrecrystallized from hexane-chlorobenzene

Sources & evidence

ORD record
ord-f0ad2806aa964415b5a3116b845acdd9
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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