反应详情

A mixture of 2-mercapto-4-methylbenzoic acid (2.0 g, 12 mmol), 2-cyanopyridine (1.4 g, 13 mmol) and pyridine (8 ml) was refluxed for 14 hrs as described in Example 9. After cooling, the precipitated crystals were collected by filtration, subjected to a silica gel column chromatography, eluted with ethyl acetate-methanol (5:1, v/v) and recrystallized from hexane-tetrahydrofuran to give the titled compound (1.4 g, 48%).

1. temperaturewas refluxed for 14 hrs
2. temperatureAfter cooling
3. filtrationthe precipitated crystals were collected by filtration
4. washeluted with ethyl acetate-methanol (5:1
5. customv/v) and recrystallized from hexane-tetrahydrofuran