Potassium Carbonate → HCID 22939400, compound

HRID 748108Notes

Reaction equation

HRID 748108 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]2[S:13][C:14]3[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=3[C:16](=[O:18])[N:17]=2)[N:7]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C:6]1[N:7]=[C:8]([C:12]2[S:13][C:14]3[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=3[C:16](=[O:18])[N:17]=2)[CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 59750183HCID 59750183, compound

Product 1

HCID 22939400HCID 22939400, compoundYield 70.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of [6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]methyl acetate (0.30 g, 1.00 mmol), potassium carbonate (0.004 g, 0.03 mmol) and methanol (30 ml) was stirred under nitrogen atmosphere at room temperature for 2 hrs. The reaction mixture was concentrated, dissolved in hot ethanol (10 ml) and filtered. The filtrate was concentrated under reduced pressure and the residue was recrystallized from ethanol to give the titled compound (0.19 g, 70%).

Workup

  1. concentrationThe reaction mixture was concentrated
  2. dissolutiondissolved in hot ethanol (10 ml)
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-e3622dbbd55f410ea75d48ccdc260048
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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