反应详情

A mixture of tert-butyl 6-cyano-2-pyridinecarboxylate (1.1 g, 5.3 mmol), methyl thiosalicylate (1.8 g, 10.7 mmol), triethylamine (2.0 ml, 14.3 mmol) and toluene (4 ml) was refluxed for 12 hrs. After cooling, the precipitated crystals were collected by filtration, recrystallized from tetrahydrofuran-hexane to give the titled compound (1.3 g, 70%).

1. temperaturewas refluxed for 12 hrs
2. temperatureAfter cooling
3. filtrationthe precipitated crystals were collected by filtration
4. customrecrystallized from tetrahydrofuran-hexane