HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine-2-carbonitrile → 2-(2-Pyridyl)-7-trifluoromethyl-4H-1,3-benzothiazine-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine-2-carbonitrile | HCID 7522 | — |
| Reactant | 2-Mercapto-4-(trifluoromethyl)benzoic acid | HCID 21542132 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-(2-Pyridyl)-7-trifluoromethyl-4H-1,3-benzothiazine-4-one | HCID 59750320 | 56% |
Reaction Steps
A mixture of 4-trifluoromethylthiosalicylic acid (2.5 g, 11 mmol), 2-cyanopyridine (1.2 g, 11 mmol) and pyridine (10 ml) was refluxed for 10 hrs. After cooling, the precipitated crystals were collected by filtration and recrystallized from tetrahydrofuran-hexane to give the titled compound (1.9 g, 54%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399759B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-4783d61c4ac84a10a282ba1284073412 |
| Source note | uspto-grants-2008_07 |