HCID 68454095, compound → HCID 59750351, compound

HRID 748184Notes

Reaction equation

HRID 748184 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[C:9]([O:12][CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)=[N:3]1>FC(F)(F)C(O)=O>[O:1]=[C:2]1[C:7]2[CH:8]=[C:9]([O:12][CH2:13][C:14]([OH:16])=[O:15])[CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)=[N:3]1

Participants

3

Reactant 1

HCID 68454095HCID 68454095, compound

Product 1

HCID 59750351HCID 59750351, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of tert-butyl 2-[[4-oxo-2-(2-pyridyl)-4H-1,3-benzothiazin-6-yl]oxy]acetate (0.30 g, 0.81 mmol) and trifluoroacetic acid (10 ml) was stirred at room temperature for 3 hrs. The reaction mixture was concentrated under reduced pressure and recrystallized from methanol-diisopropyl ether to give the titled compound (0.17 g, 67%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customrecrystallized from methanol-diisopropyl ether

Sources & evidence

ORD record
ord-d60f86f8ca5b4935a83baa13f43b62b5
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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