Pyridine-2-carbonitrile → HCID 22939340, compound

HRID 748200Notes

Reaction equation

HRID 748200 reaction equation
[SH:1][C:2]1[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=1)#[N:15]>N1C=CC=CC=1>[O:6]=[C:4]1[C:3]2[CH:7]=[CH:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:2]=2[S:1][C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[N:15]1

Participants

4

Reactant 2

HCID 7522Pyridine-2-carbonitrileHCID 4617327HCID 4617327, compound

Product 1

HCID 22939340HCID 22939340, compoundYield 42.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 2-mercaptoterephthalic acid (2.0 g, 10 mmol), 2-cyanopyridine (1.3 g, 11 mmol) and pyridine (10 ml) was refluxed for 8 hrs. After cooling, the precipitated crystals were collected by filtration and recrystallized from methanol-diisopropylether to give the titled compound (1.22 g, 42%).

Workup

  1. temperaturewas refluxed for 8 hrs
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were collected by filtration
  4. customrecrystallized from methanol-diisopropylether

Sources & evidence

ORD record
ord-cd994c0b68914ad7b1bd9a0419a288d8
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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