HCID 22939577, compound → HCID 10269150, compound

HRID 748252Notes

Reaction equation

HRID 748252 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]2[C:6](=[O:25])[N:7]=[C:8]([C:10]3[CH:15]=[C:14]([CH2:16][CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])[CH:13]=[CH:12][N:11]=3)[S:9][C:4]=2[CH:3]=1>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:27]=[CH:26][C:5]2[C:6](=[O:25])[N:7]=[C:8]([C:10]3[CH:15]=[C:14]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH:13]=[CH:12][N:11]=3)[S:9][C:4]=2[CH:3]=1

Participants

3

Reactant 1

HCID 22939577HCID 22939577, compound

Product 1

HCID 10269150HCID 10269150, compoundYield 79.3%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
0 °C

Procedure

tert-Butyl 3-[2-(7-chloro-4-oxo-4H-1,3-benzothiazin-2-yl)-4-pyridyl]propanoate (1.00 g, 2.4 mmol) was dissolved in trifluoroacetic acid (10 ml), and the mixture was stirred at 0° C. for 2 hrs. The solvent was evaporated, and the residue was recrystallized from hexane-tetrahydrofuran-methanol to give the titled compound (0.66 g, 76%) as white crystals.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was recrystallized from hexane-tetrahydrofuran-methanol

Sources & evidence

ORD record
ord-9646de3994054b17828fb5d477b44f9a
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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