HCID 22939413, compound → 6-(8-Methyl-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridinecarboxylic acid
Reaction equation
[CH3:1][C:2]1[C:11]2[S:10][C:9]([C:12]3[N:17]=[C:16]([C:18]([O:20]C(C)(C)C)=[O:19])[CH:15]=[CH:14][CH:13]=3)=[N:8][C:7](=[O:25])[C:6]=2[CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(O)=O>[CH3:1][C:2]1[C:11]2[S:10][C:9]([C:12]3[N:17]=[C:16]([C:18]([OH:20])=[O:19])[CH:15]=[CH:14][CH:13]=3)=[N:8][C:7](=[O:25])[C:6]=2[CH:5]=[CH:4][CH:3]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
tert-Butyl 6-(8-methyl-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridinecarboxylate (0.50 g, 1.4 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was stirred at 0° C. for 4 hrs. The solvent was evaporated, and the residue was crystallized from diethyl ether to give the titled compound (0.39 g, 94%) as pale yellow crystals.
Workup
- customThe solvent was evaporated
- customthe residue was crystallized from diethyl ether
Sources & evidence
- ORD record
- ord-699d37b229ab4b419616e6258854f519
- Source dataset
- uspto-grants-2008_07
- Patent number
- US07399759B2
Reaction notes
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