HCID 22939526, compound → HCID 9923377, compound

HRID 748437Notes

Reaction equation

HRID 748437 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][C:10]([O:12]C(C)(C)C)=[O:11])[CH:5]=[C:4]([C:17]2[S:18][C:19]3[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=3[C:21](=[O:23])[N:22]=2)[N:3]=1>FC(F)(F)C(O)=O>[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:4]([C:17]2[S:18][C:19]3[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=3[C:21](=[O:23])[N:22]=2)[N:3]=1

Participants

3

Reactant 1

HCID 22939526HCID 22939526, compound

Product 1

HCID 9923377HCID 9923377, compoundYield 90.7%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
0 °C

Procedure

tert-Butyl 3-[2-methyl-6-(4-oxo-4H-1,3-benzothiazin-2-yl)-4-pyridyl]propanoate (0.96 g, 2.5 mmol) was dissolved in trifluoroacetic acid (8 ml), and the mixture was stirred at 0° C. for 2 hrs. The solvent was evaporated, and the residue was recrystallized from diisopropyl ether-ethanol to give the titled compound (0.74 g, 90%) as white crystals.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was recrystallized from diisopropyl ether-ethanol

Sources & evidence

ORD record
ord-bf0075e13d9c4ac18d6d886e69662fb5
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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