HCID 22939389, compound → HCID 9925081, compound

HRID 748438Notes

Reaction equation

HRID 748438 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]2[C:6](=[O:26])[N:7]=[C:8]([C:10]3[CH:15]=[C:14]([CH2:16][CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])[CH:13]=[C:12]([CH3:25])[N:11]=3)[S:9][C:4]=2[CH:3]=1>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:28]=[CH:27][C:5]2[C:6](=[O:26])[N:7]=[C:8]([C:10]3[CH:15]=[C:14]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH:13]=[C:12]([CH3:25])[N:11]=3)[S:9][C:4]=2[CH:3]=1

Participants

3

Reactant 1

HCID 22939389HCID 22939389, compound

Product 1

HCID 9925081HCID 9925081, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
0 °C

Procedure

tert-Butyl 3-[2-(7-chloro-4-oxo-4H-1,3-benzothiazin-2-yl)-6-methyl-4-pyridyl]propanoate (0.90 g, 2.5 mmol) was dissolved in trifluoroacetic acid (8 ml), and the mixture was stirred at 0° C. for 2 hrs. The solvent was evaporated, and the residue was recrystallized from diisopropyl ether-ethanol to give the titled compound (0.74 g, 82%) as pale yellow crystals.

Workup

  1. customThe solvent was evaporated
  2. customthe residue was recrystallized from diisopropyl ether-ethanol

Sources & evidence

ORD record
ord-44a800b4e31e48d1880f30f7296b1ff5
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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