Trifluoroacetic acid → HCID 22939481, compound

HRID 748458Notes

Reaction equation

HRID 748458 reaction equation
[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:12]2[N:17]=[C:16]([CH2:18][CH2:19][O:20][CH2:21][CH2:22][C:23]([O:25]C(C)(C)C)=[O:24])[CH:15]=[CH:14][CH:13]=2)=[N:3]1.FC(F)(F)C(O)=O>>[O:1]=[C:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[S:5][C:4]([C:12]2[N:17]=[C:16]([CH2:18][CH2:19][O:20][CH2:21][CH2:22][C:23]([OH:25])=[O:24])[CH:15]=[CH:14][CH:13]=2)=[N:3]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22939336HCID 22939336, compound

Product 1

HCID 22939481HCID 22939481, compoundYield 85%

Conditions

Temperature
0 °C

Procedure

A mixture of tert-butyl 3-[2-(6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl)ethoxy]propionate (0.41 g, 1.0 mmol) and trifluoroacetic acid (5 ml) was stirred at 0° C. for 2 hrs. The reaction mixture was concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-hexane to give the titled compound (0.30 g, 85%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe residue was recrystallized from ethyl acetate-hexane

Sources & evidence

ORD record
ord-067d3a1be01842a2baf08c9f462916cb
Source dataset
uspto-grants-2008_07
Patent number
US07399759B2

Reaction notes

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