反应详情

1,3-Thiazole-2-carbonitrile (0.32 g, 2.9 mmol) and methyl thiosalicylate (0.98 g, 5.8 mmol) were dissolved in toluene (4 ml), and triethylamine (2.0 ml, 14.3 mmol) was added thereto. The reaction mixture was refluxed for 2 hrs. After cooling, the precipitates were collected by filtration and recrystallized from diisopropyl ether-ethanol to give the titled compound (0.51 g, 70%) as yellow crystals.

1. temperatureThe reaction mixture was refluxed for 2 hrs
2. temperatureAfter cooling
3. filtrationthe precipitates were collected by filtration
4. customrecrystallized from diisopropyl ether-ethanol