Methyl 4-(bromomethyl)benzoate → HCID 59750623, compound

HRID 748479Notes

Reaction equation

HRID 748479 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]([N:11]1[CH2:16][CH2:15][C:14]([CH3:30])([N:17]2[CH2:22][CH2:21][CH:20]([NH:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:19][CH2:18]2)[CH2:13][CH2:12]1)=[O:10].[CH3:31][O:32][C:33](=[O:42])[C:34]1[CH:39]=[CH:38][C:37]([CH2:40]Br)=[CH:36][CH:35]=1>>[CH3:31][O:32][C:33](=[O:42])[C:34]1[CH:39]=[CH:38][C:37]([CH2:40][N:23]([CH:20]2[CH2:21][CH2:22][N:17]([C:14]3([CH3:30])[CH2:15][CH2:16][N:11]([C:9](=[O:10])[C:3]4[C:4]([CH3:8])=[CH:5][CH:6]=[CH:7][C:2]=4[CH3:1])[CH2:12][CH2:13]3)[CH2:18][CH2:19]2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 3008907HCID 3008907, compound2×

Product 1

HCID 59750623HCID 59750623, compound

Procedure

It is prepared from (2,6-dimethyl-phenyl)-(4′-methyl-4-phenylamino-[1,4′]-bipiperidinyl-1′-yl)-methanone and 4-bromomethyl-benzoic acid methyl ester using a procedure as described for Example 52 of PCT/EP02/03871. MS/ESI 554 [M+H]+. (2,6-Dimethyl-phenyl)-(4′-methyl-4-phenylamino-[1,4′]bipiperidinyl-1′-yl)-methanone used as starting material may be prepared using a procedure similar to that described in Example 51a-e of PCT/EP02/03871. MS/ESI 406 [M+H]+

Workup

  1. custommay be prepared

Sources & evidence

ORD record
ord-4760151d161543d2afc4648d1859d7a7
Source dataset
uspto-grants-2008_07
Patent number
US07399771B2

Reaction notes

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