HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 1-[(5-Bromo-6-chloropyridin-3-yl)sulfonyl]-4-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 5-Bromo-6-chloropyridine-3-sulfonyl chloride | HCID 2793626 | — |
| Product | 1-[(5-Bromo-6-chloropyridin-3-yl)sulfonyl]-4-methylpiperazine | HCID 3957358 | 91% |
Reaction Steps
The title compound was prepared as described for Example 3 using 1-methylpiperazine and 5-bromo-6-chloropyridine-3-sulfonyl chloride. Yield: 91%: 1H NMR (CDCl3, 400 MHz) δ 8.59 (d, J=2 Hz, 1 H), 7.67 (d, J=2 Hz, 1 H), 3.08-3.01 (m, 4 H), 2.43 (t, J=5 Hz, 4 H), 2.22 (s, 3 H); 13C NMR (CDCl3, 100 MHz) δ 155.5, 146.8, 141.2, 132.7, 121.4, 54.2, 46.3, 46.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399780B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-e3dbfc542f7f41d78fed1a5ddadd66b6 |
| Source note | uspto-grants-2008_07 |