1-Methylpiperazine → 1-[(5-Bromo-6-chloropyridin-3-yl)sulfonyl]-4-methylpiperazine
Reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][C:9]1[CH:10]=[C:11]([S:16](Cl)(=[O:18])=[O:17])[CH:12]=[N:13][C:14]=1[Cl:15]>>[Br:8][C:9]1[CH:10]=[C:11]([S:16]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)(=[O:18])=[O:17])[CH:12]=[N:13][C:14]=1[Cl:15]Participants
3
Procedure
The title compound was prepared as described for Example 3 using 1-methylpiperazine and 5-bromo-6-chloropyridine-3-sulfonyl chloride. Yield: 91%: 1H NMR (CDCl3, 400 MHz) δ 8.59 (d, J=2 Hz, 1 H), 7.67 (d, J=2 Hz, 1 H), 3.08-3.01 (m, 4 H), 2.43 (t, J=5 Hz, 4 H), 2.22 (s, 3 H); 13C NMR (CDCl3, 100 MHz) δ 155.5, 146.8, 141.2, 132.7, 121.4, 54.2, 46.3, 46.1.
Sources & evidence
- ORD record
- ord-e3dbfc542f7f41d78fed1a5ddadd66b6
- Source dataset
- uspto-grants-2008_07
- Patent number
- US07399780B2
Reaction notes
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