5-Bromo-2-oxindole → 5-(Thiophen-2-yl)-1,3-dihydro-2H-indol-2-one

HRID 748524Notes

Reaction equation

HRID 748524 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2.C([Sn](CCCC)(CCCC)[C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)CCC>>[S:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[CH2:5]2

Participants

3

Reactant 2

HCID 6111935-Bromo-2-oxindoleHCID 27793732-(Tri-n-butylstannyl)thiophene

Product 1

HCID 166375085-(Thiophen-2-yl)-1,3-dihydro-2H-indol-2-one

Procedure

The title compound was prepared as described for Example 37 using 5-bromooxindole and tri-n-butyl(2-thienyl)tin: MS (ES) n/z 216 (M++1).

Sources & evidence

ORD record
ord-b1dbea2658be4e349d8b8f719350789f
Source dataset
uspto-grants-2008_07
Patent number
US07399780B2

Reaction notes

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