Sodium Hydroxide → 2H-Azepin-2-one, 3-aminohexahydro-

HRID 748578Notes

Reaction equation

HRID 748578 reaction equation
Cl.[NH2:2][C@H:3]([C:9]([OH:11])=O)[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8].[OH-].[Na+]>C(O)C>[NH2:2][CH:3]1[CH2:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]1=[O:11]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69568L-Lysine monohydrochloride

Product 1

HCID 1024632H-Azepin-2-one, 3-aminohexahydro-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
200 °C

Procedure

50 mmols of L-lysine hydrochloride 1 is neutralized with 50 mmols of NaOH and then 200 ml of ethanol is added. This mixture is heated to 200° C. for eight hours. The yield of α-amino-ε-caprolactam 2 produced by this reaction is about 47%.

Sources & evidence

ORD record
ord-e98ef7c45a6d42c2bb7042f5455131e9
Source dataset
uspto-grants-2008_07
Patent number
US07399855B2

Reaction notes

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