Sodium Hydroxide → HCID 178420850, compound

Participants

Reaction Steps

A solution of 4-thiophen-2-ylmethyl-imidazole-1-sulfonic acid dimethylamide (Intermediate-E2) (0.44 g) in 1.5 M HCl (10 mL) was heated to reflux for 3 h. The mixture was cooled to rt and basified with NaOH solution; The mixture was extracted with ethyl acetate (2×) and the organic solution was dried over Na2SO4, filtered and evaporated to give 4-thiophen-2-ylmethyl-1H-imidazole (Intermediate-E3) as a white solid ˜0.2 g.

Provenance & Evidence