Sodium Hydroxide → HCID 178420850, compound

HRID 748653Notes

Reaction equation

HRID 748653 reaction equation
CN(C)S([N:6]1[CH:10]=[C:9]([CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)[N:8]=[CH:7]1)(=O)=O.[OH-].[Na+]>Cl>[S:13]1[CH:14]=[CH:15][CH:16]=[C:12]1[CH2:11][C:9]1[N:8]=[CH:7][NH:6][CH:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 59751490HCID 59751490, compound

Product 1

HCID 178420850HCID 178420850, compoundYield 75.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 4-thiophen-2-ylmethyl-imidazole-1-sulfonic acid dimethylamide (Intermediate-E2) (0.44 g) in 1.5 M HCl (10 mL) was heated to reflux for 3 h. The mixture was cooled to rt and basified with NaOH solution; The mixture was extracted with ethyl acetate (2×) and the organic solution was dried over Na2SO4, filtered and evaporated to give 4-thiophen-2-ylmethyl-1H-imidazole (Intermediate-E3) as a white solid ˜0.2 g.

Workup

  1. temperatureto reflux for 3 h
  2. extractionThe mixture was extracted with ethyl acetate (2×)
  3. dry with materialthe organic solution was dried over Na2SO4
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-0b482ba2937e4db0a4adac616da019b8
Source dataset
uspto-grants-2008_07
Patent number
US07399868B2

Reaction notes

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