HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-(Isoquinolin-1-yl)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-isoquinolin-1-yl-1-(1-trityl-1H-imidazol-4-yl)-ethanol | HCID 59751483 | — |
| Product | 1-(Isoquinolin-1-yl)ethan-1-ol | HCID 12337920 | — |
Reaction Steps
1-Isoquinolin-1-yl-1-(1-trityl-1H-imidazol-4-yl)-ethanol (Intermediate H3) was subjected to TFA: trifluoroacetic acid, Pd/C under hydrogen similar to the catalytic reduction procedure of Method D to remove the trityl group and produced 1-1H-imidazol-4-yl)-isoquinolin-1-yl ethanol (Intermediate H4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399868B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-475e5fdc7f9143d7af559f30bcb80526 |
| Source note | uspto-grants-2008_07 |