Trifluoroacetic acid → 1-(Isoquinolin-1-yl)ethan-1-ol

HRID 748659Notes

Reaction equation

[C:1]1([C:11](C2N=CN(C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)C=2)([OH:13])[CH3:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.C(O)(C(F)(F)F)=O>>[C:1]1([CH:11]([OH:13])[CH3:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 597514831-isoquinolin-1-yl-1-(1-trityl-1H-imidazol-4-yl)-ethanol

Product 1

HCID 123379201-(Isoquinolin-1-yl)ethan-1-ol

Procedure

1-Isoquinolin-1-yl-1-(1-trityl-1H-imidazol-4-yl)-ethanol (Intermediate H3) was subjected to TFA: trifluoroacetic acid, Pd/C under hydrogen similar to the catalytic reduction procedure of Method D to remove the trityl group and produced 1-1H-imidazol-4-yl)-isoquinolin-1-yl ethanol (Intermediate H4).

Workup

customtrifluoroacetic acid, Pd/C under hydrogen similar to the catalytic reduction procedure of Method D to remove the trityl group

Sources & evidence

ORD record: ord-475e5fdc7f9143d7af559f30bcb80526
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07399868B2

Reaction notes

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