反应详情

In methanol (30 ml) was dissolved 2-[1-[(4-chlorophenyl)sulfonyl]-5-vinyloxypentyl]-1,4-difluorobenzene (0.90 g, 2.3 mmol). After addition of p-toluenesulfonic acid monohydrate (20 mg, 0.11 mmol), the resulting mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane:ethyl acetate=3:2) to yield a white solid. The resulting white solid was washed with diisopropyl ether, whereby the title compound (0.73 g, 85%) was obtained as a white powder.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customThe residue was purified by silica gel chromatography (hexane:ethyl acetate=3:2)
3. customto yield a white solid
4. washThe resulting white solid was washed with diisopropyl ether, whereby the title compound (0.73 g, 85%)
5. customwas obtained as a white powder