Hydrochloric Acid → HCID 69202069, compound

HRID 748774Notes

Reaction equation

HRID 748774 reaction equation
Cl.C(O)C.[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([CH:15]([C:27]2[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=2[F:34])[CH2:16][CH2:17][CH2:18][NH:19]C(=O)OC(C)(C)C)(=[O:14])=[O:13])=[CH:8][CH:7]=1>C(O)C.C(OCC)(=O)C>[ClH:5].[Cl:5][C:6]1[CH:7]=[CH:8][C:9]([S:12]([CH:15]([C:27]2[CH:32]=[C:31]([F:33])[CH:30]=[CH:29][C:28]=2[F:34])[CH2:16][CH2:17][CH2:18][NH2:19])(=[O:14])=[O:13])=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 59750894HCID 59750894, compound

Product 1

HCID 69202069HCID 69202069, compoundYield 176.1%

Reagents, catalysts & solvents 1

HCID 21584252Ethanol ethylacetateSolvent

Procedure

Concentrated hydrochloric acid (2 ml) was added to an ethanol solution (2 ml) of t-butyl N-[4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)butyl]carbamate (104 mg, 0.226 mmol), followed by stirring at room temperature for 2 hours. The reaction mixture was then concentrated. The residue thus obtained was recrystallized from ethanol-ethyl acetate, whereby the title compound (78.9 mg, 0.199 mmol, 88%) was obtained as colorless needle crystals.

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. customThe residue thus obtained

Sources & evidence

ORD record
ord-f030bb59db2446218568d3eed63df424
Source dataset
uspto-grants-2008_07
Patent number
US07399775B2

Reaction notes

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