Trifluoroacetic acid → 2-[3-[(4-Chlorophenyl)sulfonyl]-3-(2,5-difluorophenyl)propylamino]ethanol Hydrochloride

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Reaction Steps

In dichloromethane (5 ml) was dissolved t-butyl N-[3-[(4-chlorophenyl)sulfonyl]-3-(2,5-difluorophenyl)propyl]-N-(2-hydroxyethyl)carbamate (300 mg, 0.607 mmol) and trifluoroacetic acid (0.5 ml) was added dropwise to the resulting solution under ice cooling. After stirring at room temperature for 2 hours, the reaction mixture was concentrated under reduced pressure. To the residue was added a 1N solution (5 ml) of hydrochloric acid in ethanol, followed by concentration under reduced pressure to give a white solid. The solid thus obtained was washed with diethyl ether, whereby the title compound (249 mg, 0.579 mmol, 95%) was obtained as a white powder.

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