反应详情

Under argon atmosphere, 5-azidomethyl-2-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridine (77 mg, 0.177 mmol), palladium on carbon (14 mg), and ethyl acetate (2 ml) were added to ethanol (10 ml). The resulting mixture was stirred for 50 minutes under 1 atom hydrogen atmosphere. After filtration, the filtrate was concentrated under reduced pressure. The residue thus obtained was subjected to chromatography on a silica gel column. A fraction obtained from the elution portion with dichloromethane:methanol=10:1 was concentrated under reduced pressure, whereby the title compound (28 mg, 0.0685 mmol, 39%) was obtained as a white powder.

1. filtrationAfter filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue thus obtained