反应详情

Combine 4-bromo-2-fluoro-1-methylsulfanyl-benzene (4.8 g, 22 mmol) and sodium methanethiolate (1.6 g, 22 mmol) in DMF (50 mL). Stir for 48 hours. Pour the reaction mixture into ice (10 g). Separate the layers and wash the organic layer with aqueous saturated NaHCO3 and brine. Dry with MgSO4, filter and concentrate in vacuo. Chromatograph the residue on a column eluting with diethyl ether in hexane (0 to 5%) to give 4.82 g of 4-bromo-1,2-bis-methylsulfanylbenzene (89%).

1. customSeparate the layers
2. washwash the organic layer with aqueous saturated NaHCO3 and brine
3. dry with materialDry with MgSO4
4. filtrationfilter
5. concentrationconcentrate in vacuo
6. washChromatograph the residue on a column eluting with diethyl ether in hexane (0 to 5%)