HRID748924

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COc1ccc2c(Oc3ccc(OCCN4C=CC=CC=C4)cc3)c(-c3ccc(S(C)(=O)=O)cc3)ccc2c1.Cl

HCID68515930

未命名化合物

结构：CS(=O)(=O)c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3C=CC=CC=C3)cc2)cc1

HCID68520451

未命名化合物

PRODUCTS

生成物

结构：CS(=O)(=O)c1ccc(-c2ccc3cc(O)ccc3c2Oc2ccc(OCCN3C=CC=CC=C3)cc2)cc1.Cl

HCID68520450

未命名化合物

收率 92.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Convert the compound of Example 60 (160 mg, 0.27 mmol) to 5-[4-(2-azepin-1-yl-ethoxy)-phenoxy]-6-(4-methanesulfonyl-phenyl)-naphthalen-2-ol using a procedure similar to Preparation 15 (85%). Dissolve the free base in dichloromethane, add 1N HCl in Et2O (0.250 mL) then concentrate to give 140 mg of the title compound. Mass spectrum (ion spray): m/z=532 (M+H).

WORKUP

后处理

concentrationthen concentrate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bf76665e6b874bb68fb8a697cbb560fd
来源数据集: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07399867B2
来源说明: uspto-grants-2008_07

反应 SMILES

[ClH:1].[CH3:2][S:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:21]=[CH:20][C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:22]C)[CH:18]=3)[C:13]=2[O:24][C:25]2[CH:40]=[CH:39][C:28]([O:29][CH2:30][CH2:31][N:32]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=[CH:33]3)=[CH:27][CH:26]=2)=[CH:8][CH:7]=1)(=[O:5])=[O:4].N1(CCOC2C=CC(OC3C(C4C=CC(S(C)(=O)=O)=CC=4)=CC=C4C=3C=CC(O)=C4)=CC=2)C=CC=CC=C1.Cl>ClCCl.CCOCC>[ClH:1].[N:32]1([CH2:31][CH2:30][O:29][C:28]2[CH:27]=[CH:26][C:25]([O:24][C:13]3[C:12]([C:9]4[CH:10]=[CH:11][C:6]([S:3]([CH3:2])(=[O:4])=[O:5])=[CH:7][CH:8]=4)=[CH:21][CH:20]=[C:19]4[C:14]=3[CH:15]=[CH:16][C:17]([OH:22])=[CH:18]4)=[CH:40][CH:39]=2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=[CH:33]1