HRID748958

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCS(=O)(=O)c1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1

HCID44427405

未命名化合物

PRODUCTS

生成物

结构：CCS(=O)(=O)c1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1.Cl

HCID69073810

未命名化合物

收率 71%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID3283

Diethyl Ether

C4H10O

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Dissolve the compound of Example 88 (300 mg, 0.56 mmol) in dichloromethane (10 mL) and methanol (0.5 mL). Add 2M HCl in diethyl ether (0.4 mL) and stir for 10 minutes. Concentrate in vacuo and dry the solids in a vacuum oven at 50° C. overnight to give 224 mg of the title compound (71%): mass spectrum (ion spray): m/z=538 (M+H).

WORKUP

后处理

concentrationConcentrate in vacuo
customdry the solids in a vacuum oven at 50° C. overnight

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-91969cd9c3b448ab91d8ff660693a9c1
来源数据集: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07399867B2
来源说明: uspto-grants-2008_07

反应 SMILES

[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:16][C:15]3[CH:17]=[C:18]([OH:21])[CH:19]=[CH:20][C:14]=3[C:13]=2[O:22][C:23]2[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][N:32]3[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]3)=[CH:25][CH:24]=2)=[CH:8][CH:7]=1)(=[O:5])=[O:4])[CH3:2].[ClH:38]>ClCCl.CO.C(OCC)C>[ClH:38].[CH2:1]([S:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:16][C:15]3[CH:17]=[C:18]([OH:21])[CH:19]=[CH:20][C:14]=3[C:13]=2[O:22][C:23]2[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH2:31][N:32]3[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]3)=[CH:25][CH:24]=2)=[CH:8][CH:7]=1)(=[O:5])=[O:4])[CH3:2]