反应详情

To a solution of 2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-(piperidin-3-ylmethyl)pyrimidin-4-amine, 11c, (0.04 g, 0.11 mmol) in a 10:1 mixture of CH2Cl2/DMF (1 mL) was added iPr2NEt (0.058 mL, 0.33 mmol) and 3-methoxypropanoyl chloride (0.02 g, 0.17 mmol). After 12 hours, the solvent was concentrated in vacuo and the resulting crude was and the crude was purified by preparatory HPLC (0.1% TFA-H2O/acetonitrile) to afford the desired product, 327.

1. concentrationthe solvent was concentrated in vacuo
2. customthe crude was purified by preparatory HPLC (0.1% TFA-H2O/acetonitrile)