HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Bromo-1-(methanesulfonyl)-2-(methylsulfanyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | 4-Bromo-2-fluoro-1-(methylsulfonyl)benzene | HCID 45933720 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Bromo-1-(methanesulfonyl)-2-(methylsulfanyl)benzene | HCID 68517408 | 76% |
Reaction Steps
Dissolve 4-bromo-2-fluoro-1-methanesulfonyl-benzene (340 mg, 1.34 mmol) into DMF (8 mL) and treat with sodium thiomethoxide (103 mg, 9.8 mmol). Stir at room temperature for 2 days. Add water (10 mL) and CH2Cl2 (20 mL). Separate the layers and wash the organic layer with aqueous lithium chloride (10%), then dry (magnesium sulfate) and evaporate in vacuo. Chromatograph the residue on a SiO2 column eluting with EtOAc (20%) in hexane to give 286 mg (76%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07399867B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-a6994000eecb42a787d0729902fbe19d |
| Source note | uspto-grants-2008_07 |