反应详情

Dissolve 4-bromo-2-fluoro-1-methanesulfonyl-benzene (340 mg, 1.34 mmol) into DMF (8 mL) and treat with sodium thiomethoxide (103 mg, 9.8 mmol). Stir at room temperature for 2 days. Add water (10 mL) and CH2Cl2 (20 mL). Separate the layers and wash the organic layer with aqueous lithium chloride (10%), then dry (magnesium sulfate) and evaporate in vacuo. Chromatograph the residue on a SiO2 column eluting with EtOAc (20%) in hexane to give 286 mg (76%) of the title compound.

1. customSeparate the layers
2. washwash the organic layer with aqueous lithium chloride (10%)
3. dry with materialdry (magnesium sulfate)
4. customevaporate in vacuo
5. washChromatograph the residue on a SiO2 column eluting with EtOAc (20%) in hexane