Thionyl Chloride → HCID 87779354, compound

HRID 749046Notes

Reaction equation

HRID 749046 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[CH2:6][CH:7]([CH2:11][CH3:12])[C:8](O)=[O:9].S(Cl)([Cl:20])=O>>[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][CH:15]=1)[CH2:6][CH:7]([CH2:11][CH3:12])[C:8]([Cl:20])=[O:9]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 22595510HCID 22595510, compound

Product 1

HCID 87779354HCID 87779354, compoundYield 92.2%

Procedure

To 1.0 g (4.1 mmol) of 2-(m-trifluoromethylbenzyl)butanoic acid was added 0.98 g (8.2 mol) of thionyl chloride, and the resulting mixture was refluxed for 3 hours. Thionyl chloride was removed by an evaporator to obtain 1.0 g of 2-(m-trifluoromethylbenzyl)butanoic acid chloride as a colorless liquid.

Workup

  1. temperaturethe resulting mixture was refluxed for 3 hours
  2. customThionyl chloride was removed by an evaporator

Sources & evidence

ORD record
ord-07fe564620ef4023b369ae161162a2b2
Source dataset
uspto-grants-2008_07
Patent number
US07402548B2

Reaction notes

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