Hydrochloric Acid → (17beta)-7-methyl-3-oxo-N-[2-(trifluoromethyl)phenyl]androst-4-ene-17-carboxamide

Participants

Reaction Steps

A solution of the compound from Step B (5-3) (0.057 g, 0.12 mmol), dioxane (0.5 mL) and 1.0 N HCl solution (0.5 mL) was heated to 50° C. for 2 hr. The reaction was then concentrated to yield the desired product as an 8:1 mixture of epimers at C-7.

Provenance & Evidence