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HRID749054

反应详情

EQUATION

反应方程式

HRID 749054 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC1C=C2CC(=O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H](C(=O)Nc4ccccc4C(F)(F)F)CC[C@H]3[C@H]12
HCID69266012

未命名化合物

PRODUCTS

生成物

1
结构：CC1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H](C(=O)Nc4ccccc4C(F)(F)F)CC[C@H]3[C@H]12
HCID68973006

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

A solution of the compound from Step B (5-3) (0.057 g, 0.12 mmol), dioxane (0.5 mL) and 1.0 N HCl solution (0.5 mL) was heated to 50° C. for 2 hr. The reaction was then concentrated to yield the desired product as an 8:1 mixture of epimers at C-7.

WORKUP

后处理

  1. concentrationThe reaction was then concentrated