Benzyl Alcohol → 3-benzyloxycarbonylamino-6-methyl-2-pyridinone

Diphenylphosphoryl azide (11.9 mL, 55 mmol) was added to a solution of 2-hydroxy-6-methylpyridine-3-carboxylic acid (7.65 g, 50 mmol) and triethylamine (7.7 mL, 55 mmol) in dry dioxane (100 mL) and the resulting solution was heated to reflux. After 16 h more triethylamine (7.7 mL, 55 mmol) and benzyl alcohol (5.7 mL, 50 mmol) were added and the solution was refluxed for a further 24 h. The reaction mixture was concentrated in vacuo and the residue was partitioned between methylene chloride (200 mL) and brine (100 mL), acidified to pH 1 with 10% HCl. The organic layer was washed with saturated NaHCO3 (2×100 mL), brine (100 mL), dried over Na2SO4 and filtered. After evaporating the solvent in vacuo, methanol (100 mL) and hexane (20 mL) were added to the residue, the solid was collected, washed with methanol (50 mL) and dried to give the title compound as a white solid (7.2 g, 56%). 1H-NMR (300 MHz, CDCl3) δ 12.82 (s, 1H), 8.06 (d, J=7.0 Hz, 1H), 7.69 (s, 1H), 7.42 (m, 5H), 6.09 (d, J=7.5 Hz, 1H), 5.22 (s, 2H), 2.32 (s, 3H).

1. temperaturethe resulting solution was heated to reflux
2. temperaturethe solution was refluxed for a further 24 h
3. concentrationThe reaction mixture was concentrated in vacuo
4. customthe residue was partitioned between methylene chloride (200 mL) and brine (100 mL)
5. washThe organic layer was washed with saturated NaHCO3 (2×100 mL), brine (100 mL)
6. dry with materialdried over Na2SO4
7. filtrationfiltered
8. customAfter evaporating the solvent in vacuo, methanol (100 mL) and hexane (20 mL)
9. additionwere added to the residue
10. customthe solid was collected
11. washwashed with methanol (50 mL)
12. customdried

ORD record

ord-d38eb9a7bb2a4d0eb4bef8279547dcdb

Source dataset

uspto-grants-2008_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07402586B2