反应详情

3-(3-Methylphenylsulfonyl)amino-6-isopropyl-1-(tert-butoxycarbonylmethyl)-2-pyridinone (1.24 g, 2.95 mmol), as prepared in the preceding step, was dissolved in methylene chloride (20 mL) and reacted with trifluoroacetic acid (8 mL) at ambient temperature for 2 hours. After evaporation in vacuo, the crude product was dissolved in methylene chloride, washed with pH 7 buffer and brine, dried over MgSO4, and filtered. Evaporation of the filtrate gave the title compound (0.72 g, 67%) as a light yellow solid. Mass spectrum (LCMS, ESI) calcd. for C17H20N2O5S: 365.4 (M+H). Found: 365.1.

1. customAfter evaporation in vacuo
2. dissolutionthe crude product was dissolved in methylene chloride
3. washwashed with pH 7 buffer
4. dry with materialbrine, dried over MgSO4
5. filtrationfiltered
6. customEvaporation of the filtrate