反应详情

N′-(5-(benzyloxy)-2-cyano-4-methoxyphenyl)-N,N-dimethylimidoformamide (110 g, 356 mmol) and trifluoroacetic acid (600 ml) were heated at reflux for 15 minutes. The reaction was evaporated in vacuo and then azeotroped with toluene. The residue was triturated with diethyl ether and the solid collected by suction filtration. The solid was dried in vacuo to yield N′-(2-cyano-5-hydroxy-4-methoxyphenyl)-N,N-dimethylimidoformamide (112 g, 95% yield) as a light brown trifluoroacetate salt:

1. temperatureat reflux for 15 minutes
2. customThe reaction was evaporated in vacuo
3. customazeotroped with toluene
4. customThe residue was triturated with diethyl ether
5. filtrationthe solid collected by suction filtration
6. customThe solid was dried in vacuo