反应详情

温度

5 °C

Bromine (1.25 ml; 25 mmol) is added dropwise to a solution of 4′-isobutylacetophenone (3.52 g; 20 mmol) in 60 ml of ethanol cooled down to approximately 5° C. After stirring the reaction mixture for 30 minutes at this temperature, stirring is continued for one hour at ambient temperature. The reaction medium, to which small portions of toluene are added, is concentrated to dryness. After purification on a silica column (eluent: ethyl-heptane acetate: 5-95), a colourless oil is obtained with a yield of 57%.

1. stirringstirring
2. waitis continued for one hour at ambient temperature
3. concentrationis concentrated to dryness
4. customAfter purification on a silica column (eluent: ethyl-heptane acetate: 5-95)
5. customa colourless oil is obtained with a yield of 57%