HRID749228

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID10914757

N-benzyl-6-(4-phenylbutoxy)hexan-1-amine

C23H33NO

结构：O=c1ccc2c([C@H](CBr)OC3CCCCO3)ccc(OCc3ccccc3)c2[nH]1

HCID11583396

未命名化合物

PRODUCTS

生成物

结构：O=c1ccc2c([C@H](CN(CCCCCCOCCCCc3ccccc3)Cc3ccccc3)OC3CCCCO3)ccc(OCc3ccccc3)c2[nH]1

HCID11549412

未命名化合物

收率 54.3%

PROCEDURE

实验过程

8-(Benzyloxy)-5-[(1R)-2-bromo-1-(tetrahydro-2H-pyran-2-yloxy)ethyl]quinolin-2(1H)-one (100 mg), N-benzyl-6-(4-phenylbutoxy)hexan-1-amine (Tetrahedron Letters. 1994, 35, 9375) (112 mg) and diisopropylethylamine (77 μl) were heated in a reacti-vial at 120° C. for 4 h prior to cooling to room temperature. The mixture was purified by chromatography (Hexane-EtOAc 2:1, biotage) afforded the title compound (85 mg). LCMS RT=3.46 min

WORKUP

后处理

customThe mixture was purified by chromatography (Hexane-EtOAc 2:1, biotage)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5631daf04a634b42b19a40ff5022ede7
来源数据集: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07402598B2
来源说明: uspto-grants-2008_07

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C@@H:20]([O:23][CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][O:25]2)[CH2:21]Br)=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:30]([NH:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][O:44][CH2:45][CH2:46][CH2:47][CH2:48][C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.C(N(C(C)C)CC)(C)C>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C@@H:20]([O:23][CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][O:25]2)[CH2:21][N:37]([CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][O:44][CH2:45][CH2:46][CH2:47][CH2:48][C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1