反应详情

温度

20 °C

3-{4-[(6-Bromohexyl)oxy]but-1-ynyl}benzenesulfonamide (627 g) in IMS (1900 ml) was stirred with activated charcoal (314 g) at room temperature for 2 h and then filtered through a short pad of Celite. The filter pad was washed with IMS (4300 ml) and the filtrate transferred to a hydrogenation vessel. 5% Platinum on Charcoal (520.1 g, ˜50% water) was added and the reaction mixture was then stirred under an atmosphere of hydrogen (0.2 bar) at 20° C. for 6 h. The mixture was then filtered through a short pad of Celite and concentrated under reduced pressure to give the title compound (499 g) as a solid, LC RT=5.66 min.

1. filtrationfiltered through a short pad of Celite
2. washThe filter pad was washed with IMS (4300 ml)
3. customthe filtrate transferred to a hydrogenation vessel
4. addition5% Platinum on Charcoal (520.1 g, ˜50% water) was added
5. filtrationThe mixture was then filtered through a short pad of Celite
6. concentrationconcentrated under reduced pressure