Methyl N-[(1R,3S)-3-benzyloxycarbonylaminocyclohexyl]carbamate → methyl N-[(1R,3S)-3-aminocyclohexyl]carbamate

HRID 74924ノート

反応式

HRID 74924 の反応式
[CH2:1]([O:8][C:9]([NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][C@@H:14]([NH:18]C(=O)OC)[CH2:13]1)=[O:10])C1C=CC=CC=1.C(OC([C@H]1CCC[C@@](N)(NC(=O)OC)C1)=O)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:18][C@H:14]1[CH2:15][CH2:16][CH2:17][C@@H:12]([NH:11][C:9](=[O:10])[O:8][CH3:1])[CH2:13]1

参加物

5

反応物 2

HCID 68007620Methyl N-[(1R,3S)-3-benzyloxycarbonylaminocyclohexyl]carbamateHCID 68007622methyl N-[(1R,3S)-3-benzyloxycarbonyl-aminocyclohexyl]carbamate

生成物 1

HCID 68007555methyl N-[(1R,3S)-3-aminocyclohexyl]carbamate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

Methyl N-[(1R,3S)-3-benzyloxycarbonylaminocyclohexyl]carbamate, 19a, (1.09 g, 3.56 mmol) was dissolved in ethanol (100 mL) and treated with 10% Pd/C (0.38 g, 0.36 mmol). The flask was capped, degassed and fitted with a hydrogen balloon and allowed to stir overnight. The reaction mixture was filtered under nitrogen and concentrated in vacuo to provide the product, 19b, as a white solid.

後処理

  1. customThe flask was capped
  2. customdegassed
  3. customfitted with a hydrogen balloon
  4. filtrationThe reaction mixture was filtered under nitrogen
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-496dd94c47ba4f1da0500bcbc8bd66d5
出典データセット
uspto-grants-2014_09
特許番号
US08829007B2

反応ノート

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