反应详情

温度

80 °C

To a solution of 7-acetyl-4-(benzyloxy)-1,3-benzothiazol-2(3H)-one (68 mg) in dry THF (3 ml) under nitrogen, was added phenyltrimethylammonium tribromide (90 mg) and the mixture heated at 80° C. under nitrogen for 2 h. The mixture was diluted with water, extracted with ethyl acetate, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified on a 5 g silica SPE cartridge, eluting with stepped gradient of 10% to 100% ethyl acetate-cyclohexane mixtures, to give the title compound (49 mg).

1. extractionextracted with ethyl acetate
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. customevaporated in vacuo
5. customThe residue was purified on a 5 g silica SPE cartridge
6. washeluting