Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 6-((tert-Butoxycarbonyl)amino)hexanoic acid | HCID 637602 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69230387 | HCID 69230387 | — |
Reaction Steps
Phenethylamine (340 μL, 4.3 mmol), 6-tert-butoxycarbonylamino-hexanoic acid (1.0 g, 4.3 mmol) and 1-hydroxybenzotriazole (700 mg, 5.1 mmol) were dissolved under nitrogen in N,N-dimethylformamide and cooled to 0° C. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride was added and the mixture stirred overnight, allowing to warm to room temperature. The mixture was partitioned between water and isopropyl acetate. The organics were washed with 0.5 M citric acid, then saturated sodium hydrogen carbonate, dried over sodium sulfate and evaporated to dryness. The residue was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07402673B2 |
|---|
| Source dataset | uspto-grants-2008_07 |
|---|
| ORD ID | ord-e49fa567d0684eb48d4a7aab38c51ebe |
|---|
| Source note | uspto-grants-2008_07 |
|---|
