HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-bromo-N-[(2S)-2-(4-fluorophenyl)pent-4en-1-yl]-5-iodo-N-methylbenzamide → 3-bromo-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-5-iodo-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-bromo-N-[(2S)-2-(4-fluorophenyl)pent-4en-1-yl]-5-iodo-N-methylbenzamide | HCID 68977011 | — |
| Reactant | 3,5-Dichloro-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylbenzamide | HCID 68978638 | — |
| Product | 3-bromo-N-[(2S)-2-(4-fluorophenyl)-4-oxobutyl]-5-iodo-N-methylbenzamide | HCID 58683521 | — |
Reaction Steps
The compound was synthesized in an analogous way to that of Method 21b but using 3-bromo-N-[(2S)-2-(4-fluorophenyl)pent-4en-1-yl]-5-iodo-N-methylbenzamide rather than 3,5-dichloro-N-[(2S)-2-(4-fluorophenyl)pent-4-en-1-yl]-N-methylbenzamide (yield, 100%). 1H NMR (500 MHz, CDCl3): 2.6-3.2 (cm, 4H), 3.4-3.9 (cm, 2H), 4.0-4.2, (cm, 2H), 6.8-8.2 (cm, 7H), 9.8 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07402581B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-858dc88cdb664b3fbb8d9b27fafc17e4 |
| Source note | uspto-grants-2008_07 |